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We successfully transduced Fabry patient CD34+ hematopoietic cells with "near-clinical grade" LV/AGA in small-scale cultures and then validated a clinically directed scale-up transduction process in a GMP-compliant cell processing facility.
We further investigated the safety and efficacy of a clinically directed vector, LV/AGA, in both ex vivo cell culture studies and animal models.
However, more clinically directed inquiries, such as subjective patient experience [28, 29] and polysomnography changes with sleep apnea [30], have provided growing support to potential functional airway benefits of RME.
Among the other 8 patients, 6 had clinically directed biopsies that revealed intestinal metaplasia in 4 patients (67%).
Due to the ambiguity of the cardiac functional effects of changes in FA metabolism, clinically directed manipulation of FA metabolism must be executed with great care.
The availability of clinically directed standards would help promote the development of highly multiplexed gene expression assays in laboratory medicine [ 5].
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Although Woo et al., [ 14, 15] have employed TaqMan fluorogenic probes on leptospires, this non-clinically directed research concentrated on the use of TaqMan probes for the differentiation and identification of Leptospira species using pure isolates obtained from a reference culture collection.
Clinically, direct suture closure is usually used for repair [ 2, 3].
RHC would remain for diagnosis but would only be performed later as directed clinically.
A-928605 is also able to provide additive effects when used in combination with clinically approved agents directed against EGFR in non-small cell lung and human pancreatic tumor models.
Analogous to clinical genetic testing, clinically valid direct-to-consumer personal genome testing is not without risk, it is claimed (see also section III,2).
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