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Senior intensivists clinically adjudicated these diagnoses based on previous Sepsis-2 consensus.
Unexpectedly, the prevalence of myocardial scar was only 4.3%32(32 of 741 subjects) and was found in only 19%% of patients with a clinically adjudicated MI.
Although all the deaths were clinically adjudicated in our trial, without detailed investigations like invasive diagnostic or autopsies, a potential source of error remains.
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The primary end point was a composite of adjudicated clinically significant upper and lower GI events.
The primary end point was the cumulative incidence of CSULGIEs (including adjudicated perforations, obstructions, and clinically significant bleeds (defined as overt bleeds or a decrease in hemoglobin of ≥ 2 g/dl and/or hematocrit ≥ 10% of GI origin)).
All major bleeding events and clinically relevant non-major bleeding events were adjudicated according to the standardised model of bleeding definitions 25 (box 1).
An independent, blinded committee adjudicated any potential clinical events.
A blinded, independent committee adjudicated the secondary clinical outcomes.
Each component of the primary efficacy end point was independently adjudicated by the blinded Clinical Events Committee (for clinically driven target lesion revascularization) or by the core laboratories (for restenosis).
A well-designed randomized controlled trial that is based on clinically-relevant endpoints (i.e., all-cause mortality and adjudicated cardiovascular events) is required to provide clinical meaning to our findings and help determine whether the widespread adoption of intensified dialysis modalities such as INHD is justified.
MRIs performed between February 2003 and January 2009 to look for osteomyelitis associated with neuropathic foot lesions in subjects with diabetes where Charcot neuroarthropathy had not been suspected clinically were assessed by two independent radiologists (a third adjudicated where necessary) for the presence or absence of remote areas of signal change and osteomyelitis.
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CEO of Professional Science Editing for Scientists @ prosciediting.com