However, many confounders may further complicate the clinical picture, underlining the need for a comprehensive clinical and laboratory evaluation.
Subsequent Phase I/II trials have investigated conjugates containing paclitaxel (PNU 166945), camptothecin (PNU 166148) (both failed in clinical trials underlining the importance of rational design), and most recently HPMA-copolymer platinates (AP5280 and then AP5346-ProLindacTM) entered Phase II clinical development.
First, we present the design concepts of existing hand exoskeletons and end-effector devices and then review and discuss the clinical evidence underlining the feasibility of robot-assisted rehabilitation of hand function.
The aim of this paper is to describe the translational evidence for the use of PRP in cartilage treatment and to systematically review all the available evidence regarding the clinical application of PRP for ankle cartilage disorders, in order to understand what is the current state of the art for this specific clinical indication, underlining both limits and potential of this biological strategy.
Severely disturbed channel function corresponded to severe clinical phenotypes, underlining the important role of facilitated NMDA receptor signaling in epileptogenesis.
The emerged results supply an appreciable suggestion for the clinical practice underlining how different male sexual disorders could be influenced by different emotional patterns.
However, most of the inhibitors involved have to be administered too early to be useful in a clinical setting, underlining the need to develop interventions that target a later stage in NF-κB activation.
However, we did see a significant relationship between local Hp concentration and clinical signs, underlining again the importance of further investigations of the local role of Hp in bovine respiratory disease.
Our findings in the murine models of mice bearing congenic Neuro-2a tumours are consistent with clinical evidence underlining superior efficacy of the GvT reaction in limiting tumour growth after allogeneic BMT (Inoue et al, 2003; Li and Waller, 2004; Kanold et al, 2008).
Overall, our data report a novel p63 target gene involved in tumor suppression, and the clinical analysis underlines the biological relevance of this finding and suggests a further clinically predictive biomarker.
No one in "Jerichow" is entirely deserving of sympathy, which gives the film a detached, clinical feeling underlined by the director's habit of observing emotions rather than evoking them.
