Three percent SPL 7013, the concentration used in this clinical trial, applied vaginally to pigtailed macaques for four consecutive days did not lead to cervicovaginal tissue disruption and/or friability in any of six animals, while 5% SPL 7013 led to tissue disruption and/or friability in four of six animals [9].
There are a variety of exciting approaches to translate these new findings into clinical trials applying ACT to the majority of cancer types.
Although several clinical trials applying TENS as an abortive or prophylactic treatment for migraine have been carried out, there is no rigorous systematic review, to the best of our knowledge, investigating the effectiveness and safety of TENS in migraineurs.
The aim of this article is to assess the efficacy of yoga and other meditation-based interventions for smoking cessation, to identify the challenges of clinical trials applying mind body treatments, and to outline directions for future research on these types of therapies to assist in smoking cessation.
Clinical trials applying MMP inhibitors as a disease-modifying treatment have been proved unsuccessful due to severe side effects and inefficiency of inhibiting MMPs activity [ 22].
To our knowledge, no adverse events have been reported by other clinical trials applying RIC on a limb with a tourniquet.
Given the aforementioned clinical trials applying extracorporeal shockwave therapy in females suffering from cellulite we seek to evaluate in a large randomised-controlled trial the effects of strength training and the additional effect of shockwave therapy on the degree of cellulite.
Although safe conclusions are limited by the fact that such data are provided from studies with more early disease stages [ 26], still, they reveal that determination of the optimal therapy sequence is of high importance and needs to be further evaluated in prospective, randomized, clinical trials applying multimodal treatment.
As mentioned above, anti-inflammatory clinical trials applied at the initial phase of sepsis failed to tackle the devastating effects of sepsis and to translate into improved survival.
This review presents general aspects concerning clinical trials and cutaneous mycoses, and ends with a discussion of the design of clinical trials applied to these infections, with the aim of facilitating critical interpretation of studies published in the literature.
