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Therefore, aCGH profiling is a feasible routine clinical test with comparable results to multiprobe FISH studies; however, it may be less sensitive than FISH in cases with low-level aberrations.
The service is run as a clinical test, with a physician acting as intermediary.
Such development would be attractive as hCG β level is routinely available to clinicians as a relatively cheap, commercially available, validated clinical test with known performance characteristics.
In an ideal setting, a clinical test with the highest accuracy to identify patients with a disease (sensitivity) and those without a disease (specificity) is usually desirable.
The PLE was the most accurate and informative clinical test, with high sensitivity (0.84, 95% CI: 0.69 - 0.91) and high specificity (0.90, 95% CI: 0.85 -0.85).
The quality of a clinical test with threshold c is often expressed in a table such as Additional file 1: Table S1.
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They hope to start the first phase of clinical tests with the new virus in brain-cancer patients later this year.
"This is extremely exciting scientifically and conceptually because this could be the future of personalised medicine and we're already in clinical testing with results expected later this year," said Ugur Sahin of the Johannes Gutenburg University in Mainz, Germany who led the study published in the journal Nature.
These results were carefully compared with those obtained using the commercial mycobacteria growth indicator tube (MGIT) test via 2 sequential clinical tests (with ca. 260 clinical samples).
Several new antiviral or immunomodulatory compounds have reached preclinical or clinical testing with the aim of silencing or eradicating cccDNA to achieve functional cure.
Furthermore, until quite recently many of the therapeutic options for rosacea had not been assessed through rigorous clinical testing with meaningful outcome measures.
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