Furthermore, no clear clinical superiority of one surgical technique over another is evident.
However, volumetric assessment and RECIST have been shown not to be interchangeable, neither technique demonstrating clinical superiority [23, 24].
However, the clinical superiority of a continuous infusion (versus intermittent injection) for beta-lactams is yet to be established [60].
Several studies have assessed the clinical benefits of azacitidine compared with CCR and have shown clinical superiority, but economic evaluations are lacking.
Azacitidine, on the other hand, showed clinical superiority in terms of outcomes and improvements in safety compared with conventional treatment alternatives [9].
Therefore, double-bundle reconstructions have been proposed to replicate the anatomy of the native ACL, with literature showing no definitive clinical superiority over single-bundle techniques [17, 18].
Advancements over the past decade have expanded the variety of fixation options available; however, the clinical superiority of a particular treatment modality remains without consensus.
For surgeons, this requires demonstration of clinical superiority that is both significant and durable compared with nonsurgical management and/or with other forms of surgical treatment.
Azacitidine showed clinical superiority to all of the treatment alternatives considered and the cost-effectiveness analysis showed that azacitidine is a cost-effective treatment option in the Spanish context.
Finally, no prospective study has shown a clinical superiority of one method to another, while some retrospective reports suggest a better survival rate for endovascular cooling when compared to surface cooling methods [67, 68].
For those drugs that did not demonstrate clinical superiority (which was most of them), a simple price comparison to the existing drug was utilized as a gate toward listing.
