In some clinical studies, plasma LBP levels reflected long-term exposure to circulating endotoxin more accurately than plasma endotoxin levels [36], [37].
In clinical studies, plasma levels of CGRP can be found to be elevated during migraine and cluster headache attacks [14], [15].
In clinical studies, plasma CXCL10 concentrations are markedly elevated in septic patients and plasma CXCL10 concentrations correlate with the severity of sepsis in humans [ 4, 13, 14].
In other clinical studies, plasma CXCL10 concentrations have been shown predictive of neonatal sepsis and systemic infection in infants with high sensitivity and specificity [ 14, 15].
Aldosterone-induced cardiac fibrosis increases the stiffness of the ventricle, which may contribute to the development of ventricular dysfunction and heart failure (Struthers 2002), and in clinical studies plasma aldosterone concentrations have been correlated with left ventricular hypertrophy, vascular stiffness, and mortality (Rudolph et al. 2004).
In a prospective, controlled, clinical study, elevated plasma histamine levels have been shown to be causally associated with sepsis [7].
In the prospective clinical study, cefazolin plasma observations (n = 153) were collected from pregnant women (n = 41) during a variety of in utero surgical interventions.
Here, we present results of a clinical study where plasma D-dimers were measured in patients with C1-INH-HAE during acute attacks and after treatment with rhC1INH, and evaluate their utility as a biomarker of fibrinolyticactivity and potential probe of disease activity.
Based on these preclinical data, the cream formulation was chosen for single rising dose clinical studies, where plasma levels of MK-0873 were mostly below the LOQ, whereas skin biopsy concentrations ranged from 6.5 to 25.1 μM.
