It is believed that men with this disease pass through a series of clinical states.
This review describes these novel drugs and their targets using a clinical states model.
The current development in siRNA delivery and clinical states of siRNA-based drugs are also briefly reviewed.
Of interest, a recent pilot study examined the use of actigraphy to assess prediction for different bipolar clinical states including mania, depression, and mixed (Scott et al. 2017).
It is likely that the phenomenon of central sensitization observed in pathologic clinical states includes both of the above processes [34, 64, 65].
Positive systemic outcomes are in evidence only when TBI patients exhibit cognitive and functional improvements, if not, complete recovery from their initial clinical states consequent to traumatic events.
Trials of targeted therapy are designed on the basis of a clinical states model that describes both patient clinical risks and tumor biology.
The clinical states of monoclonal gammopathy of undetermined significance, plateau phase disease, and smoldering myeloma all suggest that a significant host-tumor interaction is taking place.
While advanced castration-resistant metastatic disease typically shows intense FDG avidity which is similar to that seen in high-grade lymphomas, FDG uptake is typically low in low-grade prostate malignancies and at early clinical states of prostate cancer.
Finally, radiology reports can be seen as a rich source of information for research, e.g. research on imaging biomarkers, because they allow linking of qualitative and quantitative information about patient pathophysiology to descriptions of clinical states and symptoms.
We discuss the implications for current theories of cortical control of the ANS and for accounts of deactivation, with particular reference to studies documenting a "failure to deactivate" in multiple clinical states.
