Exact(6)
Analytical sensitivity of DNA-based assays to detect infection with human papillomaviruses is very high, but clinical specificity for cervical cancer strongly depends on the age of the patient and case classification.
For example, we focused on novel biomarker loci displaying high clinical specificity for disease, yet the level of sensitivity of the differential DNA methylation events vary among the loci.
The translation of this into clinical specificity for natural exposure would be critical.
A 92% CIN 3 detection rate has been proposed as the clinical sensitivity along with an 85% CIN 3 confirmation as the clinical specificity for validation of all HPV assays [ 14].
VIC has a higher clinical specificity for disease but requires a dedicated virology laboratory, is less sensitive than NAT, and has a comparatively long turn-around time of 2 5 days.
If HSIL cytology were used as the endpoint for clinical evaluation, the clinical specificity for HSIL of one-occasion "high-risk" HPV positivity by the DNA sequencing method would be (2020-119)/(2020-4) = 94%; the clinical sensitivity would be 4/4 = 100%; the negative predictive value (2020-119)/(2020-119 + 0) = 100%; and the positive predictive value (ppv) would be 4/(4+115) = 3.4%.
Similar(54)
There is evidence for the clinical specificity of ragweed immunotherapy.
Because this test is designed for use only in individuals who are known to be HIV-1-positive, the clinical specificity of 97.6% is adequate for its intended use.
Accordingly, the investigation of tumour marker assays of sufficient clinical specificity and sensitivity for distinguishing between benign and malignant PEs emerged for improving the diagnostic value of cytology.
Table 3 shows the calculation of high clinical sensitivity (97%) and even higher clinical specificity (100%) of RPM-Flu for detection and identification of type A human influenza virus, compared with results from testing the same specimens with the benchmark RT-PCR-based assay.
The clinical specificity and sensitivity of this assay for both osteoporosis and extensive bone metastasis in BC have been reported previously [ 14, 15].
Write better and faster with AI suggestions while staying true to your unique style.
Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com