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The clinical sequence commonly used is an ultrafast spin-echo-planar T2-weighted sequence with parallel imaging.
The crossover sites were identified as located between the last nucleotide, differentiating the clinical sequence from the 3' partner reference sequences, and the first nucleotide, differentiating the clinical sequence from the 5' partner reference sequence.
Figure 1 shows the clinical sequence.
The availability of clinical sequence data is increasing as the technical capability to sequence clinical samples at low-cost improves.
Sinclair [ 2] noted that medical students are often attracted to medicine by a sense of idealism, but the premedical, preclinical and clinical sequence of instruction discourages them.
Users can also upload input files directly into ClinLabGeneticist after variant filtering using tools such as Cartagenia Bench Suite [ 22] or the Clinical Sequence Analyzer (CSA) from NextCode [ 23].
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We designed an RCT to evaluate genomic clinical sequencing for women and partners considering a pregnancy.
Informatic identification of clinical sequences that are nearly identical to one another may indicate specimen-to-specimen contamination or another laboratory-associated issue.
Here we review the current status of NGS technologies, challenges and applications with special consideration given to the development of clinical sequencing.
A little over one month ago, on March 21, the American College of Medical Genetics and Genomics (ACMG) announced a set of recommendations on incidental findings in clinical sequencing.
The ACMG recommendations on incidental findings in clinical sequencing are the first by any professional organization to acknowledge that genomic analysis should be aligned with the standard practice of medicine and point the way to an exciting future in which genomic information will begin to fulfill its lifesaving potential.
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