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In particular, reprogramming cells with small molecules alone is accepted to have better clinical prospects than the other reprogramming strategies.
Critical to pre-clinical and clinical prospects, long-term toxicity is further investigated after oral administration of these theranostic agents.
These data are of practical value for informing pregnant migraineurs about the typical clinical prospects and for giving advice on breastfeeding.
Among cellular reprogramming strategies, small molecule approach gets proclaimed to have better clinical prospects because it does not involve genetic manipulation.
Precisely reprogrammed cells with fewer factors should have better clinical prospects and also could facilitate the achievement of homogenous insulin producing cells, which is a major bottleneck that hampers the clinical translation of artificially reprogrammed cells.
The other potential targets, intermediate filaments and microfilaments, have remained as elusive clinical prospects.
Similar(51)
Therefore, the aim of this review is (1) to summarize the up-to-date knowledge of mechanistic studies and clinical prospect of currently available Hsp90 inhibitors, (2) to enhance our perspectives for designing and discovering novel Hsp90 inhibitors, and (3) to provide an insight into less-understood potential of Hsp90 inhibition in cancer therapy.
Furthermore, we will discuss the clinical prospect of miRNAs as diagnostic and prognostic biomarkers of HCC and their potential roles in cancer treatment.
The most promising clinical prospect of this drug class is withaferin A, a steroidal lactone that was initially isolated from Withania somnifera (winter cherry) in 1965 [ 243], and was the first member of the withanolides to be discovered.
Intervention and modulation of autophagy by using natural products can be a promising strategy to find new drug-like molecules having significant clinical prospect for the treatment of cancer.
Based on the stringent requirements for clinical application, prospects for the development of advanced functional bioceramics for tissue engineering are highlighted for the future.
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