However, many aberrations are novel or extremely rare, making clinical interpretation problematic and genotype-phenotype correlations uncertain.
This combination of factors makes the process of recruitment for such clinical trials problematic.
Moreover, we found that the ABI values correlated poorly to HRQoL, making their use as clinical anchors problematic [ 16].
It is likely that completion of scales would be inaccurate, and incomplete, validity and reliability would be in question, and clinical utility problematic.
Furthermore, the short-term nature and pre-treatment design of the study as well as the lack of direct measurements of time-related changes in tissue PARP activity and 3-nitrotyrosine (an index of peroxynitrite) make the applicability of the results to the clinical scenario problematic.
Dentin hypersensitivity (DHS) is a problematic clinical entity that may become an increasing clinical problem for dentists to treat as a consequence of patients retaining their teeth throughout life and improved oral hygiene practices.
Primary systemic vasculitides (PSV) are subgroup of autoimmune diseases associated with especially problematic clinical course often complicated by diffuse alveolar hemorrhage leading to respiratory failure.
In this study, TIMI had comparable sensitivity and specificity for MACE to that found in previously published studies [25], but again highlights that the selection of an appropriate cutoff, balancing sensitivity, specificity and clinical feasibility, is problematic.
The rare and severe nature of Duchenne makes additional clinical trials especially problematic, Penrod said.
Moreover, poor reproducibility (high inter-observer variation[8], [14]) in histologic assessment often makes clinical risk assessment problematic.
