The data are corroborated by the good metabolic stability reported for the structurally similar compound RDEA-806 (figure S2), a non-nucleoside inhibitor of HIV reverse transcriptase and clinical precedent [24], which shares the 2-thio-connector of JMN3-003 but lacks MeV inhibitory activity in our assays (data not shown).
Clinical precedent was set by adamantane inhibitors of influenza A virus (IAV) M2 in the 1960s, yet widespread resistance limits their current use.
[ 15, 16] In addition, a clinical precedent of maternal microchimerism causing hepatic GVHD in children with severe combined immune deficiency (SCID) exists.
However, because topical application of an antiretroviral drug to the mucosa is a novel prevention strategy without clinical precedent, we conducted a comprehensive systems biology assessment of tenofovir gel's effects on the mucosa.
Motivated by the clinical precedent set by inulin, we hypothesized that because our free reporters (R1, R2) are built from Glu-fib, which is likewise biologically inert, their filtration into urine following i.v. administration would be indicative of the concentration of urine.
These conclusions support the notion that hyperparathyroidism, dysregulation of bone metabolism, osteopenia, osteoporosis, and its sub-clinical precedents have a more systemic impact on overall health, implicating the opportunity for expanding the scope of therapeutic intervention to augment treatment for other related and potentially serious disorders as well.
The use of tablet computers and smartphones in the clinical setting has precedent [ 4- 7], with specialized applications already appearing for clinical use [ 8].
In April 2011, an 8-year-old cow (cow 1) died of accidental injury, with no apparent precedent clinical signs, on a farm in the canton of St. Gallen, Switzerland.
This group includes bone grafts consisting of a scaffold and growth factors (one or a few) that provide an osteoinductive effect; this is the most successful trend considering the precedents of clinical translation.
However, this Osaka symposium facilitated the concept of 'Bridging Basic Science and Clinical Hepatology', following the precedent set at the previous meeting in Florence, Italy, 2011.
Her extensive involvement in the design of the clinical trial set a precedent for statisticians to be represented on all project teams, which is now standard at Novartis.
