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These data suggest that individual SNPs will provide only a small piece of a much larger puzzle composed by a variety of (un) know clinical (phenotypic) information.
Abnormal airway remodeling and persistent dysregulation of airway tone might be the final common pathway for different disease mechanisms, and this might explain the heterogeneity of clinical phenotypic syndromes that go under the common label of "asthma".
The network operational signature transforms genotypic data (i.e., genomic alterations) to regulatory phenotypic profiles (i.e., regulatory logics/strengths), to cellular phenotypic profiles (i.e., hallmark traits) which lead to clinical phenotypic profiles (i.e., a collection of hallmark traits).
The complexity and heterogeneity of Autism Spectrum Disorders (ASD) require the implementation of dedicated analysis techniques to obtain the maximum from the interrelationship among many variables that describe affected individuals, spanning from clinical phenotypic characterization and genetic profile to structural and functional brain images.
Clinical, phenotypic and spirometric data of the subjects recruited in the AllerGene study are summarized in Table 1.
First, concordant results were obtained when using different analytical approaches and when using a stringent clinical phenotypic endpoint namely AIDS (1987 CDC criteria).
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This study was designed to identify clinical and phenotypic risk factors for clozapine-induced myocarditis.
Fifteen years after the first description, anaplastic large-cell lymphomas (ALCL) are now thought to be a heterogeneous group in terms of their clinical, morphologic, phenotypic, cytogenetic, and molecular biology features.
Because of its relatively large size, the availability of CEL files, and the wealth of clinical and phenotypic information, we chose the data set from [21] for the identification of factors.
The clinical and phenotypic information of the participants is unknown.
Clinical issue Phenotypic variability is a common feature of congenital malformations (birth defects).
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com