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However, resistance to these agents has become a major clinical obstacle.
Acquired resistance to endocrine therapies remains a major clinical obstacle in hormone-sensitive breast tumors.
One clinical obstacle to successful cure of lung cancer is the resistance to chemotherapeutic agents.
Chemotherapeutic resistance in breast cancer, whether acquired or intrinsic, remains a major clinical obstacle.
Drug resistance is the major clinical obstacle in the treatment of patients.
The development of antioestrogen resistance is a major clinical obstacle encountered in the treatment of breast cancer.
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The relevance of hypoxia with cancer biology has been increasingly observed in recent years; however, currently there are major clinical obstacles in understanding the mechanism of tumor progression and identifying the correct therapy.
Lack of early diagnosis tools is one of the clinical obstacles for effective treatment of HCC.
However, the limitations of tissue biopsy including tumor heterogeneity and insufficient tissues for molecular testing are impotent clinical obstacles for mutation analysis and lung cancer treatment.
One approach that has already demonstrated the ability to help overcome the major clinical research obstacle of subject recruitment is the CTA approach.
As institutions strive to achieve better glucose control for these patients, they are faced with both clinical and financial obstacles.
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