Lacerda turned down such criticism, claiming that clinical observation provided solid evidence for the drug's local action, on the spot surrounding the bite.
These clinical observations provided in vivo evidence that mutations in the hot-spot domain (C212-S220) of PML-RARA might contribute to the unresponsiveness to AS2O3 treatment, and the underlying molecular mechanism of PML-RARA mutations with AS2O3 resistance deserve further study.
These preclinical and clinical observations provided the rationale to initiate a phase II trial of ixabepilone to assess its efficacy in the treatment of metastatic melanoma.
Recently published clinical observations provide supporting evidence that IGFBP-5 is associated with metastasis and the aggressive tumor phenotype in breast cancer [ 9, 106].
Interestingly, although the cellular population dynamics or phenotype changes (such as naïve or central memory) over the course of the trial did not yield clear clinical correlates, the polyfunctionality kinetics did correlate with clinical observations, providing feedback for potentially improving the ACT trial design.
However, direct clinical observation only provides information about the cases occurring during the assessment period and does not provide insight into whether the procedures conducted are typical of providers or facilities.
Direct clinical observation only provides information about the cases occurring during the assessment period and does not provide insight into whether the procedures conducted are typical of the providers or facilities.
This team, which includes medical attendants who conduct HIV testing, adherence counselling, clinical observation, and provide cART to patients, visits patients who fail to show for any appointment for three months or longer and patients who have requested home-based care.
The team consists of medical attendants who do adherence counselling and clinical observation and provide combination antiretroviral therapy.
Our study provides extensive data on the relationship between histological and clinical observations and provides a standardized framework for systematic review and classification of pathological changes in liver biopsies.
