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Many important clinical milestones have been reached and the number of artificial skin substitutes licensed for clinical use is growing, but they have yet to replace the current "gold standard" of an autologous skin graft.
It has been reported that obtaining an adduction-to-abduction strength ratio of 90 100%, and an adduction strength equal to that of the uninjured side, are suitable clinical milestones for return to sport following groin injury.
It explains why a hint of desperation often creeps into CIRM press releases heralding clinical milestones.
Figure 3 summarises key clinical milestones of each patient, and table 1 shows their epidemiological characteristics.
We have shown that simple clinical milestones tend to occur at predictable times within the natural disease progression of ALS.
5 By means of the personal identification number, data for each of the registrants in NDR were linked with DNPaR to establish relevant clinical milestones for each patient.
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Survival analysis was by Kaplan Meier product limit distribution, with survival measured from clinical milestone to death or censor date.
Mean duration and standardized time from onset to every clinical milestone is given in Table 1 and displayed graphically in Fig. 1.
Sleep quality returned to pre-transplant levels by three months post-transplant, a clinical milestone at which disease outcomes are evaluated.
In September 1998, a major clinical milestone in the field of targeted therapeutics was reached when the humanised 4D5 antibody, known as trastuzumab (Herceptin), was approved by the Food and Drug Administration for the treatment of breast cancer (Baselga et al, 1996; Slamon and Pegram, 2001).
The percent technical success criteria reported by Paul and co-workers1 for compounds to reach the hit to lead, lead optimization, preclinical development and clinical development milestones are 80%, 75 %, 85, and 69% respectively.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com