The vancomycin trough achieved target in only 35 patients (20%) during routine clinical care with maintenance doses of 15 to 20 mg/kg and intervals informed by the Cockcroft-Gault creatinine clearance.
31 By contrast, variables from sources other than the medical history with similar prognostic significance for premature mortality such as blood pressure and cholesterol are collected rigorously in most clinical care and health maintenance settings.
Similarly, the CRM state can be sustained for many months in children, even though true clinical remission (maintenance of a disease-free state for 12 continuous months after medications are discontinued) is rare20.
During clinical remission, maintenance therapy is usually tapered gradually.
32 The MDHAQ can be adapted to any clinical, health maintenance or research setting, and can be completed at home.
Specific challenges related to structural (eg, interoperability, data format/entry), clinical (eg, maintenance and continuity of records, variety of coding schemes), and research-related (eg, missing data, generalizability, privacy) issues must be addressed when building an oncology-specific EMR system.
Immunosuppressive treatment included: methylprednisolone in 32 (53.3%) subjects (≤ 4 mg for clinical stability maintenance), prednisone in 2 (3.3%), chloroquine derivate in 5 (8.3%), azathioprine in 4 (6.7%), cyclophosphamide in 3 (5%), and methotrexate in 2 (3.3%).
This questionnaire can be completed before any visit in usual care, health maintenance or clinical research, so the information is available for clinical care.
Inspectors found staffing levels had an impact on "the care and treatment of patients, communication between clinical staff, the maintenance of patient records and access to staff training and appraisals".
We sought to develop and validate a surrogate end-point involving the cumulative burden of post-transplant complications to predict death/graft loss to power a randomized clinical trial of maintenance immunosuppression in pediatric HT.
