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Among the mandatory pre-surgical steps for PRG prototyping, the measurement of clinical landmarks (CL) on the bony surfaces is recognized as a key issue due to lack of standardized methodologies, operator-dependent variability and time expenditure.
Measurement planning throughout the study took place according to individual clinical landmarks (see fig 1) and did not use fixed time points starting from baseline.
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The 1-year follow-up will be the most important clinical landmark.
The clinical landmark for early diagnosis of alkaptonuria is darkening of urine upon standing, due to excretion of large quantities of HGA.
Two clinical landmark studies in 2002 demonstrated the use of therapeutic hypothermia after cardiac arrest due to ventricular fibrillation decreases mortality and improves neurological outcome [ 2, 3].
A three-year landmark clinical trial completed in 2001 called the Diabetes Prevention Program demonstrated that overweight people with prediabetes who lost a moderate amount of weight and exercised regularly reduced their risk of developing diabetes by 58%.
In the past year, three landmark clinical trials have shown that a daily dose of the antiretroviral medication Truvada can protect individuals from infection with H.I.V. — a significant discovery, given the failure so far of all efforts to develop a vaccine against the virus.
Last month, a federal drug official reported that he found repeated instances in a landmark clinical trial of Avandia, a controversial diabetes medicine, in which patients taking Avandia appeared to suffer serious heart problems that were not counted in the study's crucial tally of adverse events.
The convergent experimental data were confirmed by two landmark clinical studies published in 2002 [25 , 26.
Three recent landmark clinical trials of ocrelizumab in MS have been completed.
In the past 2 years, landmark clinical trials have shown that correction of CFTR function leads to substantial clinical benefit for individuals with cystic fibrosis.
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