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The 1-year follow-up will be the most important clinical landmark.
The clinical landmark for early diagnosis of alkaptonuria is darkening of urine upon standing, due to excretion of large quantities of HGA.
Two clinical landmark studies in 2002 demonstrated the use of therapeutic hypothermia after cardiac arrest due to ventricular fibrillation decreases mortality and improves neurological outcome [ 2, 3].
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The DDN associated leading network CSF proteins can allow the early detection of such dynamics before the catastrophic shift to the clear clinical landmarks in gliomas.
Among the mandatory pre-surgical steps for PRG prototyping, the measurement of clinical landmarks (CL) on the bony surfaces is recognized as a key issue due to lack of standardized methodologies, operator-dependent variability and time expenditure.
Measurement planning throughout the study took place according to individual clinical landmarks (see fig 1) and did not use fixed time points starting from baseline.
Moreover, optimization of device settings in CRT is an inherent part of evidence-based practice, given that it was performed in the landmark clinical trials that demonstrated the clinical benefit of CRT.
The authors describe differences in doses achieved in landmark clinical trials and those observed in routine clinical practice.
In the past 2 years, landmark clinical trials have shown that correction of CFTR function leads to substantial clinical benefit for individuals with cystic fibrosis.
During our study period, landmark clinical trials showed that BP control reduced vascular complications (3, 4) and new clinical guidelines lowered BP targets to <130/80 mmHg (11, 12).
The breast cancer study was bootstrapped onto a landmark clinical trial in Spain called Prevención con Dieta Mediterránea (PREDIMED).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com