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Biswas et al. were the first to describe the clinical hypothesis of graft-to-host transmission of HSV-1 [8].
Furthermore, a number of viruses cause similar clinical symptoms which make it difficult to choose correct diagnostic analysis under certain clinical hypothesis.
As the chest physiotherapy treatment may be dramatically different depending on the clinical hypothesis, the physiotherapist performs a lung ultrasound examination.
In the last century Gowers first advanced the clinical hypothesis of a relationship between epilepsy and migraine [1] since the two conditions show a well-recognized clinical, pathophysiological and therapeutic overlap [2].
Our results support the modern clinical hypothesis that fibrinolytic system can participate in mechanisms of such obstetric complications as pre-term pre-mature rupture of foetal membranes and placental abruption.
Indeed, immunohistochemical analysis and PCR confirmed the presence of HSV-1 in both corneal grafts, but not in the host cornea, thereby supporting our clinical hypothesis that graft-to-host ping-pong HSV-1 infection elicited this chain reaction of complications in our patient.
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Three clinical hypotheses may be proposed: pneumonia, pulmonary oedema or atelectasis.
So far, research into candidate genes has largely been based on biological and clinical hypotheses.
However, an accurate estimation of the event rate is crucial for their ability to test clinical hypotheses.
This clinical examination and chest x-rays analysis allowed the physiotherapist to propose several clinical hypotheses: pleural effusion, obstructive atelectasis or pneumonia.
We propose a multiscale computational framework of vascular adaptation to develop a bridge between theory and experimental observation and to provide a method for the systematic testing of relevant clinical hypotheses.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com