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The selection criteria were designed to replicate the clinical filtering that takes place in routine clinical practice when selecting patients for outpatient treatment.
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Step 4: Translation: the generated profiles and synthetic positive BTA cases were reviewed (via clinical filters and physician reviews) and programmed into GUARDIAN.
To this end, we created criteria E by adding the "Clinical Trial" filter to criteria A. This way, we were able to retrieve only publications based on clinical trial studies.
We used the "core clinical journals" filter in PubMed, which is an index of journals particularly relevant to practicing physicians.
The same study by Hemens et al. confirmed the high sensitivity of Clinical Queries filters for MEDLINE and EMBASE in detecting randomized controlled trials [ 11].
For example, Essential Evidence Plus contains databases such as POEMs (Patient-Oriented Evidence that Matters) providing access to synopses of new clinical research filtered for relevance to primary care.
To evaluate 2 recently described grading systems for clinical grading of filtering surgery blebs: the Moorfields Bleb Grading System (MBGS) and the Indiana Bleb Appearance Grading Scale IBAGSS).
According to the filtering clinical and histologic data, we pre-selected 79 U95Affymetrixix microarrays profiling 17 normal lung tissue samples and 62 AC tissue samples [ 49].
We accomplished this by: 1) increasing thresholds in genomic regions exempt of genes of known clinical relevance; 2) decreasing thresholds in regions with genes of known clinical relevance; and 3) filtering out known benign CNVs.
Although it would be possible to further reduce between-study heterogeneity, for example by stricter filtering on clinical prognostic factors, we believe this degree of heterogeneity reflects the reality of clinical genomic studies and likely other applications.
The clinical evaluation of the filtering ability of a bleb incorporates well-established parameters such as the extent, elevation, and vascularity of the conjunctiva at the site of surgery.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com