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Similar results were observed for the secondary clinical endpoint and across sensitivity analyses.
Surrogate endpoints are biomarkers intended to substitute for a clinical endpoint.
Cirrhosis has become the major liver-related clinical endpoint in non-alcoholic steatohepatitis (NASH).
In both cohorts, a composite clinical endpoint was defined as death, MI, unscheduled revascularisation > 3 months after the index infarction, rehospitalisation with heart failure or stroke.
The subsequent development of metastatic disease constituted the primary clinical endpoint.
The primary clinical endpoint was non-inferior 1-year target vessel failure (TVF).
A primary clinical endpoint is defined as "an event or outcome that can be measured objectively to determine whether the intervention being studied is beneficial to a patient".
Surrogate endpoints are biomarkers that are intended to substitute for a clinical endpoint and support approval for marketing authorization.
Surrogate-parameters are measureable patient characteristics intended to substitute for a patient-relevant clinical endpoint such as median overall-survival.
We reasoned that establishing its efficacy in this respect should be preliminary to investigating any clinical endpoint.
We believe the latter is a more significant clinical endpoint.
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