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Clinical difficulty to discriminate between the Alzheimer disease (AD) and dementia with Lewy bodies (DLB) has led researchers to focus on highly sensitive functional imaging modalities.
The usefulness of 90Y PET respiratory gating may be limited by the small branching ratio of positron emission in 90Y [34] and the clinical difficulty of increasing an already long acquisition time.
This may be related to less time spent outdoors and to the clinical difficulty in accurately diagnosing asthma in this age group.
The modest prognosis reflects the inherent clinical difficulty in diagnosis of small intestinal malignancy; disease may often have been present for some time before identification [ 2].
The first of the non-core modules, cell cycle, shows higher heterogeneity in all subtypes except in Luminal A. This module highlights the clinical difficulty of targeting the cell cycle with cytotoxic agents due to most tumor's high heterogeneity.
As patients with ADPKD and CKD1-4 are typically seen in the nephrology out-patient clinic setting that does not include those with CKD5 and ESRF, this should not present significant clinical difficulty.
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Moreover, prophylactic interstitial laser therapy in early pregnancy might obviate the technical and clinical difficulties in the presence of fetal decompensation in later pregnancy.
With a severe shortage in organ donors and clinical difficulties in managing allogenic transplants, bioengineered organs are a highly sought out solution for patients in end-stage organ failure.
Clinical difficulties are additionally escalated by demographic change as mentioned earlier.
The potential clinical difficulties that may result from intervention at this pattern-recognition receptor will also be explored.
Importantly, Huang et al. pre-clinical study also addressed the clinical difficulties associated with appropriate management of patients with resistant cancers with relapse.
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