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Overall, a wider use of these trial designs might lead to the identification of potential responders, ineffective drugs or combinations, and ultimately contribute to enhance the efficiency of the clinical developmental process.
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Genomic alterations, described by array-CGH, in regions that contain genes involved in luminal morphogenesis provided the first evidence for the link between these clinical entities and the developmental process [ 4].
Along the developmental process from hit finding to clinical candidate, many inhibitors did not advance beyond the stage of hit-to-lead optimization, due to their poor selectivity, physiochemical or pharmacokinetic properties.
The systematic and transparent developmental process is expected to facilitate future clinical research.
Other important factors from mouse studies of the multilevel developmental process include the effects of upregulation and downregulation of specific genes and the results at a histological and clinical level on tooth number, size and shape.
It is a part of the developmental process.
"She arrived at this style through an internal developmental process.
"It's been a developmental process for all of us.
It's a developmental process I've always taken pride in.
Once you try to audit a developmental process you kill what you wish to encourage.
With a knowledge of child development, one becomes aware that reading readiness is a developmental process.
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CEO of Professional Science Editing for Scientists @ prosciediting.com