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In the past decade, ten compounds have progressed into the clinical development pipeline, including six new compounds specifically developed for tuberculosis.
As such, it plays a critical role in helping to maintain a robust downstream clinical development pipeline.
The company's proprietary clinical development pipeline specifically addresses innovative treatments for inflammatory bowel diseases (IBD), such as ulcerative colitis and Crohn's disease, and colon infections.
In recent years, improved understanding of RSV biology and innovations in immunogen design has resulted in the advancement of multiple vaccine candidates into the clinical development pipeline.
While early discovery marks just the beginning of a very long and costly process of bringing an NME to market, it plays a critical role in helping to maintain a robust clinical development pipeline.
However, the concept of what constitutes a druggable chemical lead is evolving as more synthetically challenging molecules prepared through either semi- (e.g., Yondelis®, Ixempra®) or total synthesis (e.g., Halaven®, Aplidin®) pass through the clinical development pipeline to become marketed drugs.
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As VEGF-targeted therapies progress through clinical development pipelines, it may take several years to determine their clinical efficacy and overall response data.
3D models could therefore serve as an intermediate decision-making step in the pre-clinical drug development pipeline, linking large scale high-throughput compound screens for lead identification and increasingly expensive validation studies based on animal xenografts.
For HAT, Chagas and cutaneous leishmaniasis (CL), there are few drugs or treatments in clinical development, although a pipeline is emerging.
Although studies in this area largely focus on the clinical development aspect of the pipeline, a steady supply of quality preclinical drug candidates must be maintained at the front end to prevent downstream gaps from forming.
However, we continue to be a major tenant at Discovery Park and have around 700 research and development colleagues based at the site, working on Pfizer's mid to late stage development pipeline and developing medicines for clinical trials in a wide range of disease areas including cancer and diabetes".
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CEO of Professional Science Editing for Scientists @ prosciediting.com