Sentence examples for clinical development activities from inspiring English sources

However, American College of Rheumatology 50%ACR5050) improved benefits were less impressive, which probably led to the discontinuation of clinical development activities [ 5].

LY2456302 is a centrally-penetrant, potent, kappa-selective antagonist with pharmacokinetic properties favorable for clinical development and activity in animal models predictive of efficacy in mood and addictive disorders.

Several HDAC inhibitors are in clinical development where activity has been observed mainly in haematological malignancies.

Several PD-1 and PD-L1-blocking mAbs have now completed early clinical development with encouraging activity and safety.

Dalbavancin (DAL) is a novel semisynthetic glycopeptide in phase 3 clinical development that has activity against Gram organisms, including resistant strains.

In a phase 1 single ascending intravenous dose study in 32 subjects with RA, mavrilimumab showed a safety and tolerability profile supporting clinical development, and biological activity on acute phase reactants.

Career development activities in clinical research: The EHS Core Centers mechanism requires clinical and basic scientists with a broad range of skills to work together on a unified theme.

Vinflunine, the most recent Vinca alkaloid in clinical development, demonstrated superior antitumour activity to other Vincas in preclinical tumour models.

Three monoclonal antibodies – daratumumab, SAR650984, and elotuzumab – are in various phases of clinical development and show encouraging activity when combined with Rd in MM.

Ultimately, MDV3100 (now known as enzalutamide) was selected for clinical development because of its activity in CRPC xenograft models and its favorable drug-like properties.

A40926 is the precursor of the semi-synthetic derivative dalbavancin, which is a second generation glycopeptide currently in phase III clinical development for its improved activity, pharmacokinetics and pharmacodynamics [ 13].