A medical calculator or clinical calculator is a software program for calculating various clinical scores and indices such as body mass index (BMI), body surface area (BSA), coronary heart disease risk, individual drug dosing, etc. Usually calculation of clinical scores or indices involves complex formulas using several input parameters.
The normal clinical trial calculations and design would not necessarily hold, given the complexity of the genome and human growth, the potential effects, and the many years that it takes for results to truly manifest.
A series of phantom inserts, based on the mathematical models underlying many clinical dosimetry calculations, have been produced using 3D printing techniques.
There were no statistically significant differences between the three genotypes with regards to gender, age or clinical characteristics (calculations not shown).
All patients underwent a sequential diagnostic investigation, consisting of clinical probability calculation, a D-dimer test (Tinaquant, Roche Diagnostica, Mannheim, Germany or Vidas D-Dimer Exclusion, Biomerieux) and computed tomography scanning.
The general protocol for each patient was [ 20]: collection of baseline clinical data, calculation of entrance Sepsis-related Organ Failure Assessment (SOFA) score [ 23] and Acute Physiology and Chronic Health Evaluation (APACHE II) score [ 24] and blood sampling, all of these procedures performed within the first 24 hours of ER admission.
All patients underwent a sequential diagnostic investigation, consisting of clinical probability calculation, a D-dimer test (Vidas D-Dimer Exclusion, Biomerieux) and then randomisation to either multi-detector computed tomography alone or compression ultrasonography of the legs followed by computed tomography.
Approximately 35% of near miss events were related to one of three issues mathematical calculations, clinical judgment and communication/interpersonal skills.
Because the selection of the small VOI is not always unambiguous, in clinical practice, dose calculation is compromised, for example, to represent only the maximum dose of the kidney, and it does not take activity heterogeneity into account.
