Gene mutation frequencies did not differ significantly between clinical benefit and no clinical benefit groups.
Findings suggest a possible clinical benefit.
Herein, we found two cases with clinical benefit and one case without clinical benefit harboring BRCA2 missense mutation (Fig. 3a).
Next, we divided the cohort in patients with clinical benefit and no clinical benefit, defined as described in Methods section.
We then compared the transcriptomes of tumors from patients displaying clinical benefit to those with no clinical benefit.
A failure to do so risks rejecting drugs that offer patients additional clinical benefit.
From what I see, so far there is no added clinical benefit from the genetic tests".
"All of these different routes to lowering bad cholesterol are correlated with a clinical benefit".
As expected, there was a significant difference in patient survival when comparing clinical benefit and no clinical benefit (Supplementary Fig. 1, P = 2 × 10−7, Cox regression).
In total, we found five IPRES-enriched cases in patients with no clinical benefit and five IPRES-enriched cases without clinical benefit (P = 1, Fisher's Exact test).
Here, the clinical benefit induced by placebos represents the reward.
