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Clinical laboratories should implement an internal system to track all sequence variants identified in each gene and clinical assertions when reported.
Clinical laboratories are encouraged to contribute to variant databases, such as ClinVar, including clinical assertions and evidence used for the variant classification, to aid in the continued understanding of the impact of human variation.
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Interestingly, the limited animal [ 25] or human [ 26] data that exists does not support this common clinical assertion.
It is not recommended that these predictions be used as the sole source of evidence to make a clinical assertion.
For example, the ClinVar database allows for the deposition of variants with clinical observations and assertions, with review status tracked to enable a more transparent view of the levels of quality of the curation.
Without adequate randomized controlled clinical trials, the assertion "Since the molecular structure of GcMAF is identical to that of the native human MAF, GcMAF (even 5 - fold higher therapeutic dosage) produced no side effects" is wrong and dangerous.
These results add weight to assertions that clinical microbiology laboratories need not routinely screen for vancomycin heteroresistance in S. aureus isolates with vancomycin MICs in the susceptible range (2, 8 ).
There are prior clinical trials supporting the assertion that the addition of grid laser to anti-VEGF therapy does not significantly improve outcomes [ 19, 21].
These assertions highlight a clinical scenario that has probably changed since the findings of the consensus conference were reported.
However, we disagree with the assertions regarding the clinical relevance of our findings on the use of self-monitoring of blood glucose (SMBG) in noninsulin-treated type 2 diabetes.
"Contrary to the CIA's assertions, there is no clinical indication to use rectal rehydration and feeding over oral or intravenous administration of fluids and nutrients," Dr. Vincent Iacopino, PHR's senior medical advisor, stated in a press release.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com