Single-nucleotide polymorphism (SNP) detection is becoming important in molecular diagnostics, clinical assay, and novel drug development.
Kluk, M. J. et al. Validation and implementation of a custom next-generation sequencing clinical assay for hematologic malignancies.
For the purposes of this study, we evaluated the approach of combined WES and RNA-Seq on a research basis rather than as a full clinical assay validation.
Sequencing may be the ultimate clinical assay, providing rich information for both diagnosis, genotyping and surveillance of pathogens in a single test.
The goal of this study was to design and validate a clinical assay to detect CXCR4 mutations.
We designed and validated a customized array-comparative genomic hybridization (aCGH) platform as a clinical assay for CLL genomic profiling.
This progressive approach to developing an implementation-ready clinical assay, facilitated by computational analysis, produced a highly efficient, accurate and dependable serodiagnostics system.
The trial was designed as an open clinical assay at the Ear Nose and Throat Department Geriatric Otoneurology Clinic, and was done between 2003 and 2005.
Each microwell plate had an 8×8 array of flat-bottomed 250 μL microwells, and these microwells were used to simultaneously house the solutions for clinical assay.
When a clinical assay is stressed with extraordinarily high volume of specimens over a short period of time, extra caution may be needed to avoid systematic errors and biases.
In the second part the development process of the BCM system is described, taking into account the development of the different pump and console prototypes, the animal and mock circulation tests and, finally, the device clinical assay.
