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BCRP is known to affect the therapeutically available concentrations of various clinical agents [9 11].
We discuss recent translational discoveries in EMT and suggest additional actionable molecular pathways, biomarkers, and clinical agents.
Most HSP90 inhibitors and all clinical agents bind competitively and potently to the N-terminal ATPase pocket.
This review will discuss the discovery of these different classes, as well as their development as potential clinical agents.
Animal models are increasingly gaining values by cross-comparisons of response or resistance to clinical agents used for patients.
There is an unmet need for novel metal-based chemotherapeutics with alternative modes of action compared to clinical agents such as cisplatin and metallo-bleomycin.
Similar(24)
This liposomal formulation could potentially produce a viable clinical agent for improving the anticancer activity of Rg3.
There is the need for further research to determine the potential of 18F-FDG-labeled RBCs as a clinical agent for BPI in humans.
Therefore an agent incorporating 5-HT re-uptake inhibition coupled with 5-HT1A and/or 5-HT1B antagonismor antagonismayay provide a fast acting clinical agent.
The average r1 relaxivities of the of the surface bound complexes (obtained at 9.4 T and 25 °C) are 10.7 and 9.7 s−1 mM−1, respectively, as compared to 4.7 s−1 mM−1 for the clinical agent MagnevistTM.
Our finding that bee venom serine protease possesses fibrin ogen)olytic activity has significant implications for the use of bee venom as a potential clinical agent in the medical and pharmacological fields of hemostasis and thrombosis [11], [18].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com