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In this case, clinical abnormality and cell death results not from an abnormal polymerization of PrP, but rather from an abnormal polymerization of amyloid precursor protein (APP).
In adult men the only consistent clinical abnormality associated with a tumour of the Leydig cells is breast enlargement.
Hyoid bone tenderness is an underemphasized clinical abnormality and is described as discomfort or pain on gentle palpation of the greater cornu.
The veterinarian was notified immediately if any of the horses manifested a clinical abnormality.
In clinical settings, the objective is to determine whether an identified clinical abnormality is cancer.
Three of these seven lines had no clinical abnormality based on the standard primary phenotyping screen.
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Five days prior to inoculation, all goats were clinically examined to rule out clinical abnormalities.
Two iguanas were excluded for clinical abnormalities, and one iguana was excluded due to abnormal values on serum biochemistry.
The two most common clinical abnormalities of individuals with MVA are microcephaly and intrauterine growth retardation.
However, congenital SNHL without other clinical abnormalities is rarely diagnosed as CMV-related in early infancy.
Furthermore, defects in vagal innervation would be expected to lead to prominent clinical abnormalities outside the esophagus including gastric emptying disorders, which are uncommonly seen in achalasia.
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