In that context, the authors provide very helpful guidelines for the medicinal chemistry community on how to access the concept of activity cliffs by sharing expert insights they have gained over many systematic studies on practical aspects such as choosing the right potency difference and molecular similarity criteria to reliably define activity cliff patterns.
For individuals who are currently working, we observe higher call-back rates at the cash-cliffs, or just above the cash-cliffs; this pattern is in line with work disincentives at cash-cliffs.
The alternative – with 2015 predicted to be the year when numerous trusts risk falling off a financial and quality cliff – is an accelerating pattern of firing, hiring and more firing as a distraction from the real issues.
Scientists using the Rosetta spacecraft which arrived at 67P in August and became the first mission to orbit and land on a comet now think they may have discovered the source of these patterns on cliff faces and in deep pits: layer upon layer of rounded nodules, 1 to 3 meters across.
Prentice Hall, Englewood Cliffs] hydrogeological patterns of regional, intermediate and local groundwater flows on the scale of catchments.
Amitrano, D., Grasso, J. R. & Senfaute, G. Seismic precursory patterns before a cliff collapse and critical point phenomena.
Weathering patterns on sandstone cliff faces and sloping surfaces were studied from the viewpoint of gravity-induced stress combined with the presence of planar discontinuities in the rock.
She said the Australian labour market, tax and transfer system was not geared for those kinds of employment and income patterns, and "the cliff edges for people where their effective marginal tax rates are very high when they enter the work place is a deterrent for work".
A recent study on cliff swallows (Petrochelidon pyrrhonota) found that normal climate variations could drive variation in selection patterns (Brown et al. 2013).
Figure 2 Activity cliff example.
This "artificial cliff" causes the flow separation and the unrealistic flow pattern.
