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Sixteen (4.1%) false-positive oral-fluid results occurred in the performance study from April 15 , 2004through August 31, 2004 with unexpired devices from six test lots among 388 HIV-uninfected clients (specificity, 95.9%; 95% CI: 93.4 97.6).
From April 15 , 2004through August 31, 2004, 16 (4.1%) false-positive oral-fluid OraQuick results occurred with test devices from six different lots among 388 HIV-uninfected clients (specificity, 95.9%; 95% CI: 93.4 97.6) (Fig. 1).
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Deciphering the client specificity of Hsp110 proteins, which remains as yet unknown, will be of particular interest for future research [ 29].
In addition to their differential regulation, the various HSPs also show a large degree of functional diversity with respect to client specificity and client processing (Kampinga and Craig, 2010).
Interestingly, although overexpression of HspBP1 influenced CFTR biogenesis, it did not have any effect on glucocorticoid hormone receptor turnover, pointing towards a yet poorly understood mechanism of client specificity) [ 16].
DNAJs thus mainly confer client specificity to the Hsp70/HSPA machine, but can also affect the fate of HSPA clients, whereas NEFs seem to be mainly involved in client fate (Bukau et al., 2000; Kampinga and Craig, 2010; Young, 2014) (Fig. 1A).
Hspbp1 is one of a small group of nucleotide exchange factors for HSPA proteins that can also confer client protein specificity (reviewed in [37]).
Around 20 PDI homologues have been described in mammalian cells, many of which exhibit distinct client-protein specificities (Jessop et al, 2009b).
Despite such importance, little is known about the biochemical characteristics that regulate client interaction and specificity.
Three of these five sites (P446, P449, and V466) are near or in the cleft itself (supplementary fig. S13, Supplementary Material online), and thus likely to affect the specificity of client binding (Zhu et al. 1996), a testable scenario that is consistent with these changes being important for functional specialization of SSQ1.
The various co-chaperones assist Hsp90 by influencing its ATPase activity and by linking it to other proteins and providing some measure of specificity to the client protein-Hsp90 interaction [6].
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