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The catalytic domain of ChiA1 consists of a deep substrate-binding cleft on the top of its 8-barrel structure.
Therefore, overall it appears that the CID may enhance the exo-type activity by forming a deep substrate-binding cleft on the top of the TIM barrel [39], [43], [54].
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(Click on the top one).
In the model, helices H2 and H3 located on the top of the active site cleft may inhibit the correct positioning of the native substrate into the active site.
(on the top right).
Focus on the top.
Try on the top.
Put on the top buns.
Staple 1 on the top.
Sprinkle berries on the top.
Add foundation on the top.
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