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A large pocket surrounds the bound phosphate, with the fido motif R104 lining a smaller cleft on one side of the bound phosphate and a Y132/R107 pair lining a larger cleft on the opposite side (Figure 4B).
Transmembrane helices created an approximate circular pattern to form a substrate binding cleft on one side of the membrane.
The pre-crRNA is engaged in a binding cleft on one side of the protein and cleaved in the active site on the other side of the enzyme.
A cleft on the face of the rock provides the nesting place for what may be one of the last pairs of peregrine falcons that will nest in the state of California.
Urging caution, he added: "If you look at the face of Mark Antony, many believed he had this cleft on his chin and that's why I thought this could be him".
Other complications include disturbances in facial growth, such as a flattening of the upper-jaw region, and respiratory infections, due to the effect of the cleft on the flow of air during breathing.
The catalytic domain of ChiA1 consists of a deep substrate-binding cleft on the top of its 8-barrel structure.
Structures of the enzyme, determined by X‐ray crystallography and NMR, have shown that it adopts an α/β fold with a substrate‐binding cleft on the surface.
This structure reveals that haemanthamine targets the A-site cleft on the large ribosomal subunit rearranging rRNA to halt the elongation phase of translation.
Molecular dynamics (MD) simulations predicted binding of [Re(CO 3 dppz)(Py)]+ through a hydrophobic cleft on the fibril axis between Val18 and Phe20.
These conformational changes reflect the adaptation of the cleft on binding peptide ligands that differ in length and amino acid composition.
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