Your English writing platform
Discover LudwigExact(25)
GluA2 activation therefore involves a combination of both intra-LBD (cleft closure) and inter-LBD dimer conformational transitions.
It indicated that borrelidin may induce the cleft closure, which blocks the release of Thr-AMP and PPi, to inhibit activity of ThrRS rather than inhibit the binding of ATP and threonine.
RNA binding to the DEAD-domain then completes cleft closure to allow formation of an active ATPase site (Figure 6).
This model of cleft closure and helicase activation through regulation of α-helix 8 can reconcile published data.
Our model for the role of α-helix 8 in cleft closure of DEAD-proteins is consistent also with these properties of DExH-box RNA helicases.
By contrast, upon cleft closure in the two-domain ATP analog and RNA complexes, α-helix 8 has moved out of the RNA binding site (Figure 5).
Similar(35)
In addition, in cleft palate closure surgery, not only tracheal intubation but also pressing of the tracheal tube by a Dingman mouth gag may damage the recurrent laryngeal nerve.
In contrast, the neck linker in the leading head is kept out of its docking cleft, thus favoring closure of the cleft.
Second, fixing the upper and lower subdomains together introduces a well-defined allosteric pathway between the neck linker and the nucleotide cleft, so that closure of the nucleotide cleft by ATP becomes energetically coupled to docking of the neck linker.
Earlier studies had proposed that binding of agonists to the ligand binding domain (LBD) clefts lead to the closure of the cleft which, in-turn, opens the channel pore.
Group A consisted of 28 patients (22 males and six females) and underwent wide resection of the skin and subcutaneous tissue of the natal cleft, followed by primary closure of the wound in two layers after insertion of suction drain.
Write better and faster with AI suggestions while staying true to your unique style.
Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com