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The DNA cleavage results indicate that the complexes act as efficient chemical nucleases.
Cleavage results showed a putative tertiary structure for Cx31.1 mRNA with one region appearing to have a higher potential for antisense targeting.
To confirm the T7EN1 cleavage results, Sanger sequencing was performed and the result showed that the efficiency of miRsh-sgp53 in MEFs (Fig. 1D) and mESCs (Fig. 1E) was about 50% (6/12) and 57.1% (8/14).
There's a substantial split between live interviewer polls and polls done over the internet, and splitting the polls along that cleavage results in completely different views how opinions have shifted.
The cleavage results in double-stranded duplexes.
Such enzymatic cleavage results in inhibition of vesicle-membrane fusion and prevents the release of neurotransmitters.
This cleavage results in shedding of the ectodomain [43], [44], generating an intermediate that is recognized by Nicastrin [45], a component of the enzyme γ-secretase.
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DNA cleavage resulted from phosphate backbone alkylation (hydrolytic cleavage) and N 7) -alkylation (piperidine cleavage).
Unfortunately, these catalysts are often promoting excessive C C cleavage, resulting in a low selectivity to propanediols.
The Ca2+ ion-addition induces SPM-mediated cleavage, resulting in the release of the target protein with an extra Asp residue at the C-terminus.
In the case of plasma polymerised (pp) HMDSA, however, other reactions such as Si N bond cleavage resulted in considerably more structural diversity.
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CEO of Professional Science Editing for Scientists @ prosciediting.com