Exact(10)
Assuming a fast cleavage model of fracture, Ta, Re, Os and W are predicted to have a weak strengthening effect on Mo for the Σ5 310) tilt GB, and Mn, Fe, Co and Nb are predicted to have reasonable strengthening effects for the Σ5(100) twist GB.
Our estimate of the rate of VEGF165 cleavage by plasmin at 37°C (kp = 631 M−1s−1) was derived by directly fitting kinetic data from Keyt et al. [6] to a one-step cleavage model (described in Supplement S1, section S1; Fig. S1A).
A stepwise cleavage model, originally proposed by Takami et al., has provided valuable insights into how a single enzymatic activity generates a spectrum of Aβ peptides.
According to the sequential cleavage model of Aβ generation, γ-secretase cleavage takes place sequentially every three to four amino acids along the α-helical surface of the substrate APP, thereby converting longer Aβ peptides into shorter species [ 2, 50].
We next compared experimental cleavage distances to our simulated cleavage model, taking into account the Solexa library end-polishing procedure, which removes 3′ overhangs and fills in the complement to 5′ overhangs.
Inhibitor-treated cells showed a dose-dependent increase in CTF1 after ionomycin stimulation (Fig. 4a-b), suggesting that CTF1 is further processed by the γ-secretase complex, as predicted in our cleavage model (Fig. 2a).
Similar(50)
While models for HLA class I binding prediction exhibit a high accuracy, proteasomal cleavage models still leave room for improvements [ 36].
The localized deformation model for SCC initiation and a void-assisted film-cleavage model for SCC propagation can be used to explain the SCC susceptibility exhibited by the thermally-aged Type 310S stainless steel in supercritical water.
A cleavage fracture model of S′ needles is proposed here.
It is also shown that, because of shortages connected to the use of the Prometey probabilistic cleavage fracture model, the Unified Curve cannot be considered universally applicable.
Homogeneous catalysts have been rarely utilised due to their inherent disadvantages in respect of their difficult separation from the reaction mixture, corrosiveness (in the case of soluble acid catalysts), and, hence, are more favoured for selective bond cleavage within model compounds, but have been implemented in oxidative depolymerisation [21, 22].
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