Exact(1)
This class of RNAs guides rRNA modifications (Kiss-Laszlo et al, 1996; Ganot et al, 1997; Ni et al, 1997) and can be required for rRNA cleavage itself (Kass et al, 1990; Chu et al, 1994).
Similar(59)
It can form enzymes, for example for cleavage of itself or of other RNA, or to create peptide bonds as a fundamental constituent of the ribosome [ 1].
Poly(A) sites with EST/cDNA support whose poly(A) signals were not aligned were considered as non-conserved, even when the cleavage site itself was properly aligned.
The sequence composition at the cleavage site itself is not well characterized, but a dinucleotide preference CA was found in vitro (Chen et al., 1995).
It should be noticed that some agents behave as catalytic inhibitors, by inhibiting the cleavage reaction itself; none of them has been yet developed as an anticancer agent (Pommier et al, 1998).
With the DNA cleavage action itself showing no sequence preference, the specificity of ZFN and TALEN is determined by their DNA-binding domains, which can be engineered to recognize specific sequence in the gene of interest.
The polyadenylation signal and DSE were clearly observed, and the cleavage site itself exhibited a strong BA dinucleotide bias (B = C, G or T), in agreement with the previously reported CA dinucleotide.
The leader protease (Lbpro) performs the initial cleavage by freeing itself from the growing polypeptide chain; subsequently, Lbpro cleaves the two homologues of the host cell protein eukaryotic initiation factor 4G (eIF4G).
But the battle over the draft is really a proxy for a more fundamental fight over Israeli identity itself, a cleavage here that some see as a far greater threat to the future of the state than its external enemies.
This interaction leads to interference on the physiological processing of APP: BRI2 restricts the docking of γ-secretase to APP and the access of α- and β-secretases to their cleavage site on APP itself.
Nothing however is known with regard to ovarian cancer as a source of TTR itself or cleavage products thereof.
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