Sentence examples for cleavage factor from inspiring English sources

Combined with recent work demonstrating the direct involvement of A12.2 in Pol I nucleotide incorporation, this study further supports the concept that A12.2 cannot be viewed solely as a cleavage factor.

In addition, Casein Kinase 2 was found to be required for the phosphorylation of Npl3 and affect its ability to compete against Rna15 (Cleavage Factor I) for binding to polyA signals.

In yeast, the cleavage/polyadenylation machinery, which is composed of the Cleavage Factor I (CFI) (CSTF in humans) and Cleavage/Polyadenylation Factor (CPF) (CPSF in humans) complexes, is responsible for the recognition of polyA/termination signals and their subsequent processing [2] [6].

Subunits of the cleavage factor Im complex may regulate 3′UTR length [ 35].

The cleavage factor Hrp1 also shuttles and can contribute to cytoplasmic surveillance (González et al., 2000).

For example, HRP1 and CLP1, both induced in response to MMS, are subunits of cleavage factor I, required for the cleavage and polyadenylation of 3' mRNA ends [ 90].

Whereas all known cellular Pols possess cognate protein factors that stimulate cleavage of the nascent RNA, Pols I and III have incorporated their cleavage factors as bona fide subunits.

Although it is not yet clear why these polymerases have incorporated their cleavage factors as subunits, a picture is emerging that identifies roles for these subunits beyond providing nucleolytic activity.

However, the fidelity of transcription can be further improved by a factor of 10-1-10-2 during the proffreading of transcription via transcript-assisted and cleavage factor-assisted (Gre in bacteria, TFIIS in eukaryotes and TFS in archaea) removal of erroneous nucleotides [ 15, 25- 27].

In mammals, these factors have been termed (by consensus) as CPSF (Cleavage and Polyadenylation Specificity Factor), CstF (Cleavage stimulatory Factor), CFI and CFII (Cleavage Factors I and II), and PAP (poly(A) polymerase)[ 2].

Also conserved are the sequences adjacent to the common ABHD1 and Sec12 polyadenylation sites suggesting that they may be important recognition sites for pre-mRNA cleavage factors.