Taken together, these findings suggest that PS1 participates physically in a complex with APP during the γ-secretase cleavage event.
This three-part paper shows that most problems encountered with the original Beremin model result from an unnecessarily oversimplified description of the local cleavage event.
In the presence of Fe(II) ·BLM, the ECL DNA biosensing switch undergoes an irreversible cleavage event that can trigger a significant increase in ECL intensity.
Taken together, these results suggest a novel cleavage event of apoE4, generating an amino-terminal fragment that localizes within NFTs of the AD brain.
The mature catalytic domain was obtained by a trans cleavage event under acidic conditions and crystallized in the absence of a bound inhibitor.
Following shedding of the extracellular domain, a second cleavage event occurs at site S3 within the transmembrane domain mediated by the multicomponent protease γ-secretase, resulting in the release of the Notch intracellular domain (NICD).
This cleavage event is indistinguishable from the N-terminal cleavage of OPA1 observed in CGNs undergoing caspase-mediated apoptosis (Loucks et al., 2009) and results in removal of a key lysine residue (K301) within the GTPase domain.
This allowed us to assess conditions that may control this cleavage event.
The CatD processing represents the primary cleavage event in the degradation of yolk proteins.
This latter processing is known as the secondary cleavage event and is unique to marine teleosts.
This cleavage event exposes a reactive thioester that allows covalent attachment of C3b to target surfaces.
