The native state unfolded at 100(±20) pN, elongating 10FNIII by 12(±2) nm and reaching a clearly marked intermediate that unfolded at 50(±20) pN.
At intermediate levels of cAMP, a fast and a slow decay component (representing cAMP-bound, unfolded sensors, and free, folded sensors) were clearly distinguishable (data not shown).
A Decade of PhoThe from London's Southborderkate police
A box on that page states clearly that the conventional narrative of how those portentous events unfolded is based largely on the interrogation under torture of key witnesses who have never been permitted a single moment in a publicly observed court of law.
This result clearly demonstrates that CHIP protects folded p53 conformation, which was getting unfolded due to APP metabolism in HEK-APP cell.
The resulting CSI plot generated for the α-carbons of residues 245 288 of Fe3+-HO2O clearly demonstrates that this C-terminal region is present as an unfolded and dynamic random coil.
Hiratsuka et al. [ 26] explained clearly that YKS inhibits neuronal death during ER stress by regulating the unfolded protein response.
UP1 clearly exhibits preferential binding to the G-quadruplex structure as compared with its binding to unfolded or unstructured DNA.
As shown in Fig 4C this mutant was active and formed an adduct with HOIP clearly indicating that removal of Cys885 does not trivially remove a residue required for Zn2+ coordination resulting in unfolded protein.
The gray matter could be clearly seen in the MRI image, and we used the midline of the gray matter to construct the unfolded map of the cortex (Van Essen and Maunsell 1980).
