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The activation pattern for 3D SfT was clearly more extensive than that for 3D SfS (compare yellow and blue voxels in Figure 2).
However, clearly more extensive research is necessary to substantiate this assumption.
Clearly, more extensive mutagenesis of surface residues within this highly conserved domain will be required to tease out its function.
Moreover, glial proliferation was clearly more extensive in the temporal than in the nasal half (GFAP, figure 4Cc).
Although high expression of E2F1 in VHL-defective renal cancer is associated with senescence and has been suggested to be protective in the context of renal cancer, caution is warranted in designating E2F1 as oncogene or tumor suppressor gene for which clearly more extensive investigation is required.
Clearly, more extensive investigation of Golgi retention/retrieval needs to be undertaken in cells with other TNFRSF1A mutations before we can confidently state whether this mechanism of induction of NF-κB activity is unique to the C73R mutation in TNFRSF1A, or is perhaps instead a more common mechanism of TNFR1 dysfunction in TRAPS.
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Clearly, a more extensive analysis of yir expression in the other stages of the P. yoelii life cycle and location of the YIR proteins within different parasite stages is needed to address whether functionally distinct subsets of YIR exist.
Clearly, a more extensive prospective study with more patient samples is needed to further warrant this conclusion.
This is likely to depend on the biological context such as cell, tissue and disease type, as well as on the expression of other genes related to the malignant process; this clearly warrants more extensive and thorough investigation.
Less is known about leukaemic cultures with respect to the relevant enzymes of the urea cycle, and clearly a more extensive series of analyses is required before we can establish whether the relationship with mRNA copy number per cell for argininosuccinate synthetase holds fast (work in progress) as in melanomas and hepatocellular carcinomas.
Clearly, ONRLDB provides more extensive coverage than NRLiSt, for both, the number of ligands and the number of orphan NRs covered.
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CEO of Professional Science Editing for Scientists @ prosciediting.com