Quite clearly larger scale, randomized controlled trials are needed to determine whether iron supplementation in low birth weight / premature infants affects neurodevelopment (short and long term) and long term growth, and to comprehensively monitor potential adverse effects.
Clearly, large-scale screening with better technology or improved design might be an inspiring way to uncover additional new CAMs, or identify already known synaptic proteins such as CAMs, to provide a better understanding of the physiology and pathology occurring during synapse development.
Clearly, large-scale evolutionary changes occurred in S4 after (or at) the Bacteria and Archaea divergence, and yet the signatures are unvarying within each domain.
Flow visualization observations show clearly that large scale eddy mixing can be generated in regions between sharp edges.
We did not detect clearly such large scale deformations, but further, higher resolution, microscopy in Drosophila embryos will be needed to investigate a possibility of a similar phenomenon.
Although the exploration of this emerging topic is still in its infancy, the advances so far are encouraging and clearly directed to large scale applications.
This is clearly impossible on a large scale, but conceptually desirable, for example, in prospectively assessing heat stress exposure as a risk factor for human performance, morbidity, and mortality at the population level.
Large scale topography clearly controls algal patch structure.
The fatigue performance of reinforced concrete slabs was investigated under clearly defined bending conditions with large scale tests.
But it has clearly not led to the large scale change that was envisioned in policy documents developed in the years immediately after apartheid ended.
