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In adults there is a clearly established association between DM and the development of malignancy.
Again, changes in markers indicative of clinical relevance or clearly established association with a plausible underlying mechanism are key to interpretation.
Another clearly established association [ 3, 4, 6, 8- 12] was the second strongest in our study: SNP rs7574865 in the third intron of the STAT4 gene (OR = 1.62).
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The findings clearly establish the association of ACE I/D gene polymorphism with the renal failure.
This study clearly establishes this association through a detailed analysis of the clinical and radiological aspects in a group of patients of non-Anglo-Saxon origin.
Officials said they had not clearly established a connection.
These underlying medical conditions may have also caused the falls that resulted in the patients' fractures, an association clearly established in the literature [1].
People drinking excessively and receiving advice had higher AUDIT scores and were more likely to be male than those who did not receive advice, but no other associations were clearly established.
However, in most cases, these experiments should only be undertaken when the initial association signal is clearly established.
The obesity-related cardiometabolic risk factors (i.e. abnormal lipid profile and insulin resistance) are associated to an excess of central adiposity in adults, but this association is not clearly established in pre-school children [ 18, 21].
Thus, this association has been clearly established in the mouse hippocampus by experiments involving CB1 receptor gain of function (CB1 receptor pharmacological agonism) and loss of function (CB1 receptor genetic inactivation, CB1 receptor pharmacological antagonism) conducted in various in vitro (tissue slices, cell cultures) and in vivo (whole mice) experimental systems.
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CEO of Professional Science Editing for Scientists @ prosciediting.com