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This could be achieved by the development of an international protocol enabling a clearly defined case definition for IEI-EMF and a validated screening tool, with active involvement of medical practitioners.
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Study designs should clearly define cases and controls and measurement of phenotypes.
Our solution focusses on a clearly defined use case: collaborative prospective electronic collection of longitudinal person-related data.
Ivermectin is the gold standard for treatment, although the optimal dosage is not clearly defined in case of HS/DS.
If assays are only evaluated on sera from clearly defined clinical cases, the true performance on samples submitted from everyday clinical practice where the diagnosis is unresolved and with a low pretest probability, will not be known [ 19].
Beyond the weak relationship of neuronal firing to the the phase of the population oscillation, the decay of the AC0F in the noisy limit cycle case means that phase is not very clearly defined in the case of noisy limit cycles; there is certainly no asymptotic phase one could use to establish isochrons.
Another major factor is to have a clearly defined role for case managers.
Consider steady-state class I with R* = 0 and R_EGF* = 0. CIE* and CDE* are not clearly defined in this case, but according to the conditions on the initial values we derived, we know that R0 < CDE0 + CIE0.
In humans, male infertility is a more clearly defined entity in cases of azoospermia or severe oligospermia (Hull et al, 1985; Silber, 2000).
In building such a coherent data set a caution is necessary as the dayside magnetopause at high-latitudes may be less clearly defined than in the case of observations at low latitudes.
Nowhere is this goal more clearly defined than in the case of malaria, where adaptive evolution in the form of drug resistance continues to undermine efforts to control human disease caused by P. falciparum [ 1] and P. vivax [ 2].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com