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Though some mutations clearly dampened protein expression, deletion of amino acids 57 70, corresponding to the predicted 3rd alpha helix of α-mating factor secretion signal, increased secretion of reporter proteins horseradish peroxidase and lipase at least 50% in small-scale cultures.
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Compared to WT mice, AMPKα1−/− mice clearly had dampened circadian rhythm of core temperature (Fig. 4A).
But if there is pressure, it clearly has not dampened his zeal.
K-means clustering of the complete set of genes is consistent with Figure 1, but the inclusion of ~5,000 genes that are not clearly responsive leads to dampened curves and three non-responsive clusters (and consequently merging of three pairs of the original clusters) (Additional file 1).
"The combination of a lackluster job market and high foreclosure activity is clearly having a dampening effect on the housing market".
In the midst of his 20-hour visit here, Mr. Bush was clearly concerned about dampening expanding questions about the intelligence failures before the Sept. 11 attacks, including questions about what he knew.
"With Scottish house prices hardly rising at all, it is inappropriate for the recovery to be dampened across the UK for what is clearly a local or regional issue centred on London".
Until I actually went to the [genetics centre] and that doctor probably explained it a lot more clearly, and to me it [feeling of guilt] sort of dampened down and from then on.
"Clearly new supply always dampens leasing velocity for a period of time, but 110,000 square feet isn't going to give anybody any broad concern for that marketplace over time," Mr. Lee said.
It was in fact, as the 2015 order's detractors have pointed out themselves, a period of unprecedented growth and economic prosperity, which the Title II regulation of a huge proportion of Americans' internet access clearly did little to dampen.
This study has shown quite clearly that the cortisol response to the cold hand stress test was considerably dampened in women at the end of pregnancy.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com