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Rozerem targets the same receptors as the over-the-counter aid melatonin, but with potentially clearer efficacy.
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Although there is an increase in the planned sample size under these designs, due to the sequential nature, substantial sample size reductions compared with the single-stage design is also possible not only in the case of clear efficacy but also in the case of complete lack of efficacy of the new treatment.
The review of the literature about the effects of mazindol at therapeutic doses (1 6 mg/d) confirms its clear efficacy profile in the treatment of excessive daytime sleepiness and cataplexy, with no potential for abuse, no withdrawal syndrome, and rare serious adverse events, even after a long-term exposure.
Varenicline, an approved smoking cessation medication, showed clear efficacy in reducing alcohol consumption in heavy-drinking smokers.
In an editorial accompanying the duo, Duke University professor Geraldine Dawson laments the lack of definitive findings or clear efficacy of the myriad options laid out in front of autistic parents, all of them involving expense of time and money.
Despite exciting preclinical data with various approaches, there are only a few examples of clear efficacy in clinical trials.
Despite exciting preclinical data with various delivery methods, there are only few examples of clear efficacy in clinical trials and all of these trials have employed local delivery [4] [9].
We did not observe any evidence of anti-bacterial activity using LRR proteins carrying the 3020insC mutation while Nod1 LRR domains also demonstrated a clear efficacy in this assay.
CE vaccines seek to focus responses on the most conserved segments of HIV-1 in order both to elicit CTL responses considered obligatory for viral control and to avoid CTL responses toward variant peptides that allow escape without hindering viral function and that may act as immunological decoys with no clear efficacy in terms of viral control.
To date, pharmacological treatment trials have failed to show clear efficacy.
Several selective inhibitors of mTOR have been evaluated without clear efficacy.
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CEO of Professional Science Editing for Scientists @ prosciediting.com